Progression of 14-3-3σ in nasopharyngeal carcinoma
10.3760/cma.j.issn.1673-422X.2011.06.012
- VernacularTitle:14-3-3σ及其在鼻咽癌中的研究进展
- Author:
Wang KUN
;
Yi BIN
- Publication Type:Journal Article
- Keywords:
14-3-3 Proteins;
Nasopharyngeal neoplasms;
Methylation
- From:
Journal of International Oncology
2011;38(6):435-438
- CountryChina
- Language:Chinese
-
Abstract:
14-3-3σ,an vital tumor suppressor which is regulated by p53,plays a key role in cell cycle regulation, apoptosis, migration and proliferation, affecting tumor formation, invasion and metastasis. The methylation inactivation of 14-3-3σ is widely recognized as one of the mechanisms of tumorigenesis,and be associated with the metastasis of NPC.
