Targeting the IL-6/STAT3 signaling pathway in cancer treatment
10.3760/cma.j.issn.1673-422X.2011.06.009
- VernacularTitle:IL-6/STAT3信号传导通路及其在肿瘤靶向治疗中的作用
- Author:
Yuqi GUO
;
Duan ZHENFENG
;
Zhan ZHANG
- Publication Type:Journal Article
- Keywords:
Neoplasm;
Interleukin-6;
STAT3;
Signaling pathway
- From:
Journal of International Oncology
2011;38(6):427-429
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-6(IL-6)is associated with cancer staging, survival, apoptosis and the sensitivity to chemotherapeutic drugs, and it is overexpressed in the cancer tissue and serum of cancer patient.IL-6 Can regulate proliferation and differentiation of cancer cells through IL-6/STAT3 signaling pathway. Therefore, blocking IL-6/STAT3 signaling pathway has potential therapeutic implications for cancer.
