Effects of invigorating Qi and promoting blood circulation drugs combined with compound triamcinolone acetonide on interleukin 2 and tumor necrosis factor in patients With oral lichen planus
10.3760/cma.j.issn.1673-4246.2011.08.003
- VernacularTitle:补气活血中药联合复方曲安奈德对口腔扁平苔藓患者血清IL-2及TNF水平的影响
- Author:
Xianguo LIU
- Publication Type:Journal Article
- Keywords:
Oral lichen planus;
Chinese medicine;
Compound triamcinolone acetonide
- From:
International Journal of Traditional Chinese Medicine
2011;33(8):681-683
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of invigorating qi and promoting blood circulation drugs combined with compound triamcinolone acetonide on the interleukin 2 and tumor necrosis factor in patients with oral lichen planus. Methods 43 patients with oral lichen planus were randomly recurited into two groups by means of random number table.The control group was treated with prednisone orally, 30 mg/d, then reduced to IS mg/d at first two weeks, and further reduced to S mg/d at first three weeks. Maintained the dose for four to eight weeks. While the treatment group was treated with 40 mg compound triamcinolone acetonide at injury area by local injection,which was mixed with 2% lidocaine hydrochloride injection, once a week, continuous therapy for 2 months. Qi regulating and blood activating drugs were also added to the treatment group, with 150ml each time, once a day for 2 months. The clinical symptoms were observed, serum interleukin 2 and tumor necrosis factor were detected before and after the treatment. Results Compared with the control group, serum interleukin 2 and tumor necrosis factor in the treatment group decreased significantly after treatment [IL-2 (2.58± 0.32)ug/L, TNF(156.45+13.67)ng/L,P＜0.05]. Serum interleukin 2 and tumor necrosis factor decreased significantly after the treatment in the control group [IL-2(5.21±0.53) μg/L, TNF (205.02±15.75) ng/L,P＜ 0.05]. The total effective rate of the treatment group and the control group was 86.4% and 66.7% respectively, there was a significant difference (x2=3.321,P＜0.05).Conclusion Invigorating qi and promoting blood circulation drugs combined with compound triamcinolone acetonide on oral lichen planus was better than prednisone.
