Progress in the mechanism of plasma N-terminal pro-brain natriuretic peptide in children with Kawasaki disease
10.3760/cma.j.issn.1673-4408.2011.04.013
- VernacularTitle:川崎病患儿血浆中N末端脑利钠肽原升高机制的研究进展
- Author:
Lian WANG
;
Yanwen SHEN
- Publication Type:Journal Article
- Keywords:
Mucocutaneous lymph node syndrome;
Peptide fragments;
Natriuretie peptide
- From:
International Journal of Pediatrics
2011;38(4):350-352
- CountryChina
- Language:Chinese
-
Abstract:
Kawasaki disease ( KD) is an acute febrile systemic vasculitic syndrome. Since there is no specific diagnostic test for KD, the diagnosis is mainly based on the clinical menifetations according to the criterias and excluding of other diseases. Recently the value of plasma brain natriuretic peptide ( BNP) in the diagnosis of KD has been paid more attention gradually. The plasma NT-proBNP level is significantly elevated in KD patients in the acute phase. It is of some specificity and sensitivity, and it may due to the local myocardial inflammation, cytokines and diastolic function of left ventricular. This review summarizes the mechanisms by which the elevated levels of plasma NT-proBNP occur in the acute phase of KD.
