Values of continuous renal replacement therapy in the treatment of multiple organ dysfunction syndrome induced by sepsis
10.3760/cma.j.issn.1671-0282.2011.06.011
- VernacularTitle:持续性肾脏替代治疗在脓毒症诱发多脏器功能失常综合征患者中的应用价值
- Author:
Xinbiao HE
;
Wei ZHAO
;
Suying YAN
- Publication Type:Journal Article
- Keywords:
Sepsis;
Continuous renal replacement therapy;
Multiple organ dysfunction syndrome
- From:
Chinese Journal of Emergency Medicine
2011;20(6):600-603
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the values of continuous renal replacement therapy (CRRT) for the treatment of multiple organ dysfunction syndrome ( MODS) induced by sepsis. Methods A total of 62 patients with MODS were divided into three groups, namely non-CRRT group, short period CRRT group (24 ~ 48 h) and long period CRRT group( >48 h). Relevant factors including organ function, plasma endothelin-1 (ET-1),sepsis-related organ failure assessment(SOFA)score, average length of survival time and accumulative survival rate were analyzed . Results Compared with non-CRRT group, a statistically significant difference in SOFA score was evident on the 4th day after long period CRRT group and on the 6th day after short period CRRT group. The survival rates of three groups on the third day after treatment were 56. 3% 、 83.3% and 88.9%, respectively (P< 0.05). The survival rates of three groups three weeks after treatment were 53. 1% , 58. 3% and 66.7% , respectively (P>0.05). The average lengths of survival time in three groups were(4.4 ±2.6)days, (9.5 ±6. l)days and (10.3 ±5.4)days, respectively. Compared with non-CRRT group, the average lengths of survival time were longer in the other two groups. The levels of serum ET-1 significantly decreased after CRRT treatment (P<0.05). Conclusions The organ function and survival rate could be improved by CRRT. Average lengths of survival time were significantly prolonged in two CRRT groups(P <0.05). More effective therapeutic results including lower SOFA score and longer average length of survival time were observed when the course of CRRT was extended longer properly.
