Dual effects of neutrophil gelatinase associated lipocalin on neoplasmas
10.3760/cma.j.issn.1673-4203.2011.06.012
- VernacularTitle:中性粒细胞明胶酶相关脂质运载蛋白作用于肿瘤的二重性
- Author:
Yijun WANG
;
Lin PENG
- Publication Type:Journal Article
- Keywords:
Neutrophil gelatinase-cussociated lipocalin;
Lipocalin2;
Neoplasms
- From:
International Journal of Surgery
2011;38(6):396-399
- CountryChina
- Language:Chinese
-
Abstract:
Neutrophil gelatinase associated lipocalin(NGAL),also known as lipocalin 2,has close relationship with human neoplasias,which is up-regulated in a number of malignancy and involves in the process of tumor development.But it appears to exist paradoxical effects attributed to NGAL in human neoplasias.For instance,through protecting MMP9 from autodegradation,NGAL has a clear pro-tumoral and pro-metastatic effect,as has already been observed in breast cancer and esophageal cancer.However,on the contrary,for pancreatic cancer and ovarian cancer,NGAL can inhibit FAK phosphorylation and vascular epidermal growth factor synthesis,having an anti-tumoral and anti-metastatic effect.This review summarizes the current knowledge about the dual effects of NGAL in the process of tumor development,and attempts to explore the possible underlyins mechanism.
