Linezolid for treatment of nocardiosis in systemic lupus erythematosus: a case report and literature review

VernacularTitle:利奈唑胺治疗系统性红斑狼疮并发奴卡菌病一例分析
Author: Lei ZHOU ; Lu GONG ; Zongfang ZHANG ; Xiaomin DU ; Kunkun WANG
Publication Type:Journal Article
Keywords: Lupus erythematosus,systemic; Nocardia infections
From: Chinese Journal of General Practitioners 2011;10(8):585-587
CountryChina
Language:Chinese
Abstract: This report presented a case of disseminated infection with nocardia in lupus erythematosus (SLE) and reviewed the current literature. Nocardiosis was a rare, sometimes life-threatening opportunistic infection in SLE patients. The isolation and identification of pathogen was fundamental for the diagnosis of nocardiosis. Sulfonamides were traditionally the agent of choice for treatment of nocardiosis; while it must be given for several months even more than one year, particularly in patients with suppressed immune function. Issues regarding the drug resistance and the toxicity of sulfonamides in long-term therapy needed to be considered. Linezolid could be an effective agent for the treatment of nocardiosis, whether it could reduce the treatment course need to be further studied.