Roles of IL-8 and eotaxin in airway inflammation and lung function injury of chronic obstruction pulmonary disease
10.3760/cma.j.issn.1671-7368.2011.08.019
- VernacularTitle:白细胞介素-8和嗜酸粒细胞趋化因子在慢性阻塞性肺疾病气道炎症及肺功能损害中的作用
- Author:
Xia ZHU
;
Zenglian TIAN
- Publication Type:Journal Article
- Keywords:
Interleukin-8;
Chemotactic factors,eosinophil
- From:
Chinese Journal of General Practitioners
2011;10(8):579-580
- CountryChina
- Language:Chinese
-
Abstract:
The clinical data of 25 patients with acute exacerbations of chronic obstruction pulmonary disease (AECOPD) admitted from March 2009 to October 2010 were analyzed. The sputum samples were collected and the levels of inflammatory cell, interleukin-8 (IL-8) and eotaxin in sputum were determined. The lung function was measured. Twenty healthy subjects served as controls. The counts of neutrophils and eosinophils, and the levels of IL-8 and eotaxin in sputum of AECOPD were higher than those of health subjects. There was a positive correlation between the levels of IL-8 and the counts of neutrophils (P < 0. 01), and between the levels of eotaxin and the counts of eosinophils in sputum ( P < 0.01). The levels of IL-8 and eotaxin were negatively correlated with the lung function (FEV1% ).
