Effect of local subhypothermia on oxyradicals and inflammatory reaction in patients with acute cerebral infarction

VernacularTitle:局部亚低温对急性脑梗死氧自由基及炎症反应的干预作用
Author: Min BI ; Desheng WANG ; Suijun TONG ; Qilin MA ; Hongli QU ; Jianpeng LI ; Kunmu ZHENG ; Yidan ZHANG
Publication Type:Journal Article
Keywords: Cerebrovascular accident; Hypothermia induced
From: Chinese Journal of General Practitioners 2011;10(7):507-509
CountryChina
Language:Chinese
Abstract: Forty five patients with acute cerebral infarction were randomized to two groups: in treatment group patients received local subhypothermia and conventional therapy, in control group patients received conventional therapy only. Clinical outcome was assessed by the National Institutes of Health Stroke Scale (NIHSS) on admission and at 7, 14 and 30 d after treatment. Serum neuron specific enolase (NSE), nitrogen monoxide ( NO ) , superoxide dismutase (SOD), interleukin-6 (IL-6 ) and intercellular adhesion molecule-1 (ICAM-1) were detected on admission and at 7,14 d after treatment The study showed that NIHSS scores of treatment group on 14, 30 d were lower than those of control group ( P ＜ 0. 05 ). Serum NSE, NO, IL-6 and ICAM-1 levels significantly decrease; while serum SOD levels increased (P ＜ 0. 05). In conclusion, local subhypothermia therapy can inhibit inflammatory reaction, reduce oxygen free radical formation and improve neurological function in patients with acute cerebral infarction.