A new anti-cancer target: ADAM10
10.3760/cma.j.issn.1673-422X.2011.07.004
- VernacularTitle:抗癌治疗新靶标——去整合素金属蛋白酶10
- Author:
Yuan PAN
;
Xuehua DING
- Publication Type:Journal Article
- Keywords:
Cell adhesion molecules;
Neoplasm metastasis;
ADAM protein
- From:
Journal of International Oncology
2011;38(7):492-495
- CountryChina
- Language:Chinese
-
Abstract:
Gene ADAM10 (a disintegrin and metalloproteinase 10) is a member of ADAMs gene family. The corresponding membrane protein contains a disintegrin domain and a metalloproteinase domain. It is involved in various biological events such as cell adhesion, cell fusion, cell migration, and membrane protein shedding and proteolysis. ADAM10 protein is overexpressed in many tumors, which interacts with adhesion molecules and critical signaling molecules associated with cancer development and tumor progression, and promotes tumor invasion and metastasis. Regulating the expression of ADAM 10 can inhibit tumor invasion and metastasis , which may become a new strategy for anticancer therapy.
