Matrix metalloproteinase-2(MMP-2)and MMP-9 or tissue inhibitors of metalloproteinase-2( TIMP-2) and TIMP-1 and kidney diseases
10.3760/cma.j.issn.1673-4408.2011.04.033
- VernacularTitle:MMP-2、MMP-9及其抑制剂TIMP-2、TIMP-1与肾脏疾病
- Author:
Guixia TONG
;
Xiaojing HU
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinases;
Tissue inhibitors of metalloproteinase;
Kidney
- From:
International Journal of Pediatrics
2011;38(4):416-419
- CountryChina
- Language:Chinese
-
Abstract:
Alterations in the balance between synthesis and degradation of extracellular matrix( ECM) and its remodeling may result in an accumulation of ECM molecules and lead to tubulointerstitial fibrosis and glomerulosclerosis and end-stage renal failure. The major physiologic regulators of ECM degradation in the glomerulus are matrix metalloproteinases ( MMP). Tissue inhibitors of metalloproteinase-2 and-1 (TIMP-2 and TIMP-1)are endogenous inhibitors of MMP-2 and MMP-9 respectively. The expression or activity of MMP and TIMP is different in all kinds of kidney diseases or pathophysiological processes. This article reviews the interrelationship of MMP-2, MMP-9, TIMP-1, TIMP-2 and kidney diseases.
