Relationship between tumor tolerance to TRAIL and its receptors

VernacularTitle:肿瘤细胞TRAIL耐受与其受体的关系
Author: Wen OUYANG ; Conghua XIE
Publication Type:Journal Article
Keywords: TNF-related apoptosis-inducing ligand; Drug resistance; neoplasm; Receptors; TNF-related apoptosis-inducing ligand
From: Journal of International Oncology 2011;38(7):483-485
CountryChina
Language:Chinese
Abstract: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in tumor cells but not in normal cells. It induces apoptosis in its target cells by interacting with surface death receptors DR4 and DR5,which contain a cytoplasmic region designated as thedeath domain. Clinical use of rhTRAIL and its agonistic antibodies is limited due to partial or completetolerance to TRAIL in human tumor cell lines. As TRAIL binding to its death receptors is the initial and crucial step in initiating apoptosis, the mechanisms of TRAIL-tolerance in tumor cells is closely related to the expression,location,distribution and function of TRAIL receptors . Personalized care combined with other therapies targeting TRAIL receptors may be expected to overcome the TRAIL-tolerance of tumor cells eventually.