Interferon regulatory factor 4: regulate and control of lymphocyte
10.3760/cma.j.issn.1673-4408.2011.04.031
- VernacularTitle:干扰素调节因子4对淋巴细胞调控研究进展
- Author:
Gu JUN
- Publication Type:Journal Article
- Keywords:
Interferon regulatory factor 4;
Transcription factor;
T helper cells;
B cells
- From:
International Journal of Pediatrics
2011;38(4):410-413
- CountryChina
- Language:Chinese
-
Abstract:
Interferon regulatory factors(IRF)are key factors in interferon induction. IRF4, a member of the IRF family of transcription factors, is expressed in cells of the immune system where it transducers signals from various receptors to activate or repress gene expression. IRF4 expression is a key regulator for the development T helper cell subsets and B lymphocyte differentiation. A series of recent studies have further demonstrated critical functions for IRF4. This review focuses on the recent advances on roles of IRF4, including infection, autoimmune disease and immune malignancy. A better understanding of IRF4 will hopefully provide new biomark and potentially guide the design of novel therapeutic approaches.
