Pathogenesis of radiation-induced stomatitis
10.3760/cma.j.issn.1673-422X.2011.06.022
- VernacularTitle:放射性口腔黏膜炎的发病过程
- Author:
Qinghua DU
;
Rensheng WANG
- Publication Type:Journal Article
- Keywords:
Stomatitis;
Radiotherapy;
Pathologic process;
Risk factors
- From:
Journal of International Oncology
2011;38(6):465-467
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced stomatitis is a frequent side effect for head and neck cancer patients undergoing radiotherapy, which affects both the treatment and the life quality. The direct effects of radiation, oxidative stress, transcription factor, proinflammatory cytokine and pathogenic microorganism are involved in the onset of radiation-induced stomatitis. The pathologic process can be divided into five phases including initiation, up-regulation, amplification, ulceration and healing. Understanding of the pathogenesis and risk factors provides basis for prevention and control of radiation-induced stomatitis.
