Influence of organic anion transporting polypeptide (SLCO1B1 and SLCO1B3) genetic polymorphisms on mycophenolic acid in Chinese kidney transplantation patients
10.3760/cma.j.issn.0254-1785.2011.07.004
- VernacularTitle:有机阴离子转运体1B1和1B3基因多态性对肾移植受者血麦考酚酸浓度的影响
- Author:
Duojiao WU
;
Ming XU
;
Xuanchuan WANG
;
Qunye TANG
;
Ruiming RONG
;
Tongyu ZHU
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Mycophenolic Acid;
Organic anion-transporting polypeptide;
Polymorphism,single nucleotide
- From:
Chinese Journal of Organ Transplantation
2011;32(7):393-395
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between the genetic polymorphisms of organic anion transporting polypeptide (SLCO1B1 and SLCO1B3) and mycophenolic acid ( MPA)pharmacokinetics in Chinese kidney transplant recipients. Methods Gene mutations (SLCO1B3T334G, SLCO1B1 A338G) were detected in 68 recipients by PCR-LDR. The plasma samples were collected and blood concentration of MPA was measured on the 28 th day after transplantation. The area under the curve (AUC)0-12 of MPA in different genotype recipients was compared to analyze the correlation between single nucleotide polymorphisms (SNPs) and MPA pharmacokinetics. Results MPA AUC0-12 was higher in SLCO1B3 T334G GG carriers group than in TT carriers [(54. 54 ±14.40)vs(37.30±12.88)mg·h·L-1,(P=0.052)].However,there was no difference in MPA AUC0-12 among each genotype of SLCO1B1 A338G (P>0. 05). Conclusion Genetic polymorphisms of SLCO1B3 affect interindividual variety in plasma MPA concentration in Chinese kidney transplantation recipients.