Hypothesis of 'saturated or nonsaturated cytotoxicity model' clarifies antibodies mediated immunoreaction in transplant recipient
10.3760/cma.j.issn.0254-1785.2011.06.008
- VernacularTitle:"器官移植受者体液免疫现象的""饱和-非饱和杀伤""假说"
- Author:
Bicheng CHEN
;
Hui GUO
;
Yong LIU
;
Sheng CHANG
;
Yong CAI
;
Peng XIA
;
Shaoling ZHENG
;
Yirong YANG
- Publication Type:Journal Article
- Keywords:
Transplantation;
Antigen-antibody reactions;
Saturated;
Cytotoxicity
- From:
Chinese Journal of Organ Transplantation
2011;32(6):351-354
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop the hypothesis ‘saturated or non-saturated cytotoxicity model' and explain the various phenomena of antibody mediated immunoresponses in recipients,including rejection and accommodation.Methods The imitating complement dependent cytotoxicity.The threshold set to identify as saturated or non-saturated cytotoxicity depends on antigen-antibody complex(R)whether or not above lethal number(D)in effective time.Feasibility of the hypothesis was examined through explaining various phenomena mediated by anti-donor antibodies,especially some contradictory phenomena.Results Hyperacute rejection,accelerated rejection and acute rejection could be well explained by saturated cytotoxicity.Accommodation of ABO imcompatible transplantion,de novo antibody induced injury,change of protein profile,and C4d deposition in graft could be well elucidated by the hypothesis.Conclusion The hypothesis saturated or nonsaturated cytotoxicity model' help to interpret and interconnect various phenomena of antibodies mediated immune response,such as rejection and accommodation.
