Cellular immunology function test and individualized immunology adjustment of pan-drug resistant Acinetobacter baumannii infected patients after liver transplantation
10.3760/cma.j.issn.0254-1785.2011.06.007
- VernacularTitle:肝移植后泛耐药鲍曼不动杆菌感染者的细胞免疫功能监测和免疫抑制方案调整
- Author:
Ruidong LI
;
Jiayong DONG
;
Hao YIN
;
Jun MA
;
Zhiren FU
;
Zhengxin WANG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Immune monitoring;
Pan-drug resistance;
Acinetobacter baumannii;
Infection
- From:
Chinese Journal of Organ Transplantation
2011;32(6):347-350
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the monitoring and the individualized adjustment of cellular immunology function in the recipients infected with pan-drug resistant Acinetobacter baumannii(PDR-Ab)after liver transplantation.Methods We retrospectively summarized the infection and the prognosis of PDR-Ab in 299 cases of liver transplantation performed from Jan.2008 to May 2010.The absolute number of T lymphocytes and ATP level within CD4+ T cells were monitored,and T cell immunology function(TCIFS)was scored.According to different immunology adjusting proposals,14 cases of PDR-Ab infection were divided into 2 groups:(1)traditional group,routine anti-infective therapy;(2)individualized group.Individualized immunology adjustment was made according to the score of TCIFS besides routine therapy.Results There was no significant difference in age,MELD and Child-pugh score between two groups.The peri-operative bleeding volume in individualized group was more than that in traditional group(P<0.01).There was no significant difference in TCIFS score between two groups at 1st week after transplantation and the onset of the PDR-Ab infection.However,the score in individualized group was apparently higher than that in traditional group when anti-infection therapy ended(P<0.05).The difference in the recovery rate between two groups was significant(P<0.05).No rejection happened in two groups.Conclusion It is an effective way to decrease the mortality of PDR-Ab infection after liver transplantation that the individualized adjustment of immunosuppression protocols is guided by grading quantitatively the cellular immunology function according to the absolute number of T lymphocytes and ATP level within CD4+ T cells.
