Clinical value of Hangzhou Criteria in selection of patients with hepatocellular carcinoma for living donor liver transplantation
10.3760/cma.j.issn.0254-1785.2011.06.003
- VernacularTitle:肝移植治疗肝癌的受者选择杭州标准在亲属活体供肝移植中的应用价值
- Author:
Shusen ZHENG
;
Kai WANG
;
Xiao XU
;
Qi LING
;
Jun CHEN
;
Min ZHANG
;
Weilin WANG
;
Jian WU
;
Zhikun LIU
;
Haijun GUO
- Publication Type:Journal Article
- Keywords:
Hangzhou Criteria;
Hepatocellular carcinoma;
Living donor;
Liver transplantation;
Prognosis
- From:
Chinese Journal of Organ Transplantation
2011;32(6):330-333
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of Hangzhou Criteria in selection of patients with hepatocellular carcinoma(HCC)for living donor liver transplantation(LDLT)and their effects on recipient's post-transplant survival.Methods A retrospective analysis was conducted on 43 patients with HCC who underwent LDLT in our center.All of the recipients were classified into subgroups according to Milan Criteria,Up-to-Seven Criteria and Hangzhou Criteria,and post-transplant total survival rate and tumor-free survival rate were compared among the criteria.Results The number of patients within Hangzhou Criteria was 61.5 %(8/13)more than that within Milan Criteria and 23.5 %(4/17)more than that within Up-to-Seven Criteria.The 1-,and 3-years total survival rate and tumor-free survival rate of the recipients within Milan Criteria(n=13)were 100 %,80.0 % and 84.6 %,84.6 %,those of the recipients within Up-to-Seven Criteria(n=17)were 100 %,75.2 % and 87.5 %,81.2 %,and those of the recipients within Hangzhou Criteria(n=21)were 100 %,80.0 % and 89.5 %,84.2 %,respectively.There was no significant difference among the three criteria in total survival rate and tumor-free survival rate(P>0.05).Conclusion Hangzhou Criteria further enrolled more liver transplantation candidates without decline of total survival rate and tumor-free survival.It is a more effective selection of HCC recipients for LDLT.
