Advances on WT1, PRAME, ERG genes in acute myeloid leukemia
10.3760/cma.j.issn.1673-4408.2011.04.025
- VernacularTitle:WT1、PRAME、ERG基因在急性髓系白血病中的研究进展
- Author:
Liu QING
- Publication Type:Journal Article
- Keywords:
Gene;
Leukemia;
Minimal residual disease
- From:
International Journal of Pediatrics
2011;38(4):390-392
- CountryChina
- Language:Chinese
-
Abstract:
Specific fusion genes of leukemia are currently the main biomakers for minimal residual disease (MRD)monitoring. Recent studys have found that the WT1, PRAME, ERG genes may be the potential acute leukemia related molecules, and can be used to monitor acute myeloid leukemia's MRD, directing clinical stratified therapy and estimating prognosis. This article reviews the pathogenesis, incidence of these genes and the relationship to the clinical prognosis.
