Simultaneous liver-kidney transplantation: Single-center study
10.3760/cma.j.issn.0254-1785.2011.05.006
- VernacularTitle:肝肾联合移植的单中心经验总结
- Author:
Lai WEI
;
Zhishui CHEN
;
Fanjun ZENG
;
Changsheng MING
;
Zhonghua CHEN
;
Dungui LIU
;
Bin LIU
;
Nianqiao GONG
;
Jipin JIANG
;
Dunfeng DU
- Publication Type:Journal Article
- Keywords:
Combined liver and kidney transplantation;
Hepatorenal syndrome
- From:
Chinese Journal of Organ Transplantation
2011;32(5):272-275
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the curative effect of simultaneous liver and kidney transplantation (SLKT) for patients with end-stage liver and kidney diseases and liver cirrhosis patients with hepatorenal syndrome.Methods All SLKTs (n=21) performed at our center from January 1999 to December 2010 were reviewed and SLKT outcomes were compared with those of kidney transplantation (KT) (n=609) and liver transplantation (LT) (n=133) performed during the same period.Results There were 3 deaths due to infection 2 weeks, 6 months and 5 years respectively after operation. One patient died due to multiple organ dysfunction syndrome 2 weeks after operation. One patient was dead 5 years after operation because of rejection. MELD level between SLKT and LT had no significant difference, but serum creatinine in SLKT group was significantly higher than in LT group (516.0±329.9 vs 111.4±138.1 mmol/L, P<0.01). The 1-year acute kidney rejection rate and rate of delayed graft function (DGF) of the kidney had no significant difference between SLKT group (0 vs 9.5 %) and KT group (6 % vs 17.3 %). There was no significant difference in one-, 3- and 5-year patient survival rate between SLKT group (87.7 %, 67.8 % and 67.8 %) and LT group (84.2 %, 73.5 % and 69.4 %).Conclusion SLKT is a safe and effective treatment for end-stage liver and kidney diseases.
