A comparative study of pancreatic endocrine function and related metabolism after long-term survival between the patients with combined kidney-pancreas transplantation vs those with combined en bloc' liver-pancreas transplantation
10.3760/cma.j.issn.0254-1785.2011.05.003
- VernacularTitle:胰腺联合肾脏或肝脏移植后长期存活受者胰岛功能及相关代谢的比较研究
- Author:
Xiaofeng ZHU
;
Xiaoshun HE
;
Feiwen DENG
;
Yi MA
;
Dongping WANG
;
Anbin HU
;
Guodong WANG
;
Weiqiang JU
;
Linwei WU
;
Qiang TAI
- Publication Type:Journal Article
- Keywords:
Combined multiple organs transplantation;
Pancreas transplantation;
Portal vein drainage;
Systemic venous drainage;
Pancreatic function
- From:
Chinese Journal of Organ Transplantation
2011;32(5):264-267
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of combined ‘en bloc' liver-pancreas transplantation (LPT) with portal vein drainage and simultaneous combined kidney-pancreas transplantation (KPT) with systemic venous drainage on the pancreatic endocrine function and related metabolism.Methods Four LPT patients and 6 KPT ones with normal hepato-renal function, good quality of life and periodic follow-up received measurement of serum insulin, insulin provocation test, fasting glucose, oral glucose tolerance test, C-peptide, glycated hemoglobin, triglyceride and total cholesterol; and their laboratory test parameters were compared and analyzed.Results In KPT group, 2-h insulin level, C-peptide level and total cholesterol level were significantly higher at 6th month, 3rd and 6th month postoperation (all P<0.05). But there was no significant difference in other parameters between the two groups at 6th month after operation.Conclusion Either KPT or LPT can achieve excellent endocrine function, carbohydrate and lipid metabolism; and the results show that portal venous drainage does not offer major metabolic advantages within 6 months after operation.
