The management and prognosis of postmastectomy local recurrence in 477 breast cancer patients
10.3760/cma.j.issn.1007-631X.2011.06.013
- VernacularTitle:乳腺癌术后局部复发的治疗及预后分析
- Author:
Xiaoqing WANG
;
Sheng ZHANG
;
Yan LIU
;
Peng LIU
;
Jin ZHANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Neoplasm recurrence,local;
Prognosis
- From:
Chinese Journal of General Surgery
2011;26(6):489-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore an optimal treatment and to study the prognosis related factors of breast cancer patients with local recurrence after mastectomy. Methods From 2002. 7 to 2005. 2, 477female patients with loco-regional recurrence of breast cancer treated in Tianjin Cancer Hospital were analyzed retrospectively. Results In 477 cases, recurrence within 1 year after mastectomy accounted for 26. 2% , recurrence within 2 years accounted for 61. 2%. There were 310 cases with metastasis after local recurrence was diagnosed, accounting for 65.0%. 5-year total survival rate after recurrence is 48.4%.Local control rates varied in subgroups with different recurrence site, clinical subtypes, radiotherapy fields,with or without radiotherapy, surgical resection or excisional biopsy ( P<0. 05 ). There was a statistical difference in distant metastasis rate and 5-year survival rate among subgroups which had different clinical stage of primary tumor, disease-free interval, clinical subtypes or treatment methods ( P<0. 05 ). Simplistic treatment option, late clinical stage of primary tumor and triple-negative breast cancer were the independent factors predicting poor prognosis for recurrent breast cancer ( P<0.05 ). Conclusions Multi-site recurrence and triple-negative breast cancer lead to a poor local control. Local expansion of radiotherapy combined with surgery improves the local control rate. Patients with late clinical stage of primary tumor,recurrence within 2 years, triple-negative breast cancer are likely to have distant metastasis when recurrence is diagnosed. Combined treatment program improves survival rate.
