The clinical study of chemically-modified chitosan anti-adhesion film in the prevention of postoperative intra-abdominal adhesion
10.3760/cma.j.issn.1007-631X.2011.05.017
- VernacularTitle:改性壳聚糖防粘连膜预防腹部手术后腹腔粘连的临床观察
- Author:
Li REN
;
Ye WEI
;
Yunshi ZHONG
;
Shixu Lü
;
Dexiang ZHU
;
Jianmin XU
- Publication Type:Journal Article
- Keywords:
Postoperative complications;
Abdominal cavity;
Adhesions;
Chemically-modified chitosan,anti-adhesion film
- From:
Chinese Journal of General Surgery
2011;26(5):414-416
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate a chemically-modified chitosan anti-adhesion film in the prevention of intestinal adhesion after abdominal surgery.Method In this study 240 patients at the Department of Surgery, Fudan University Zhongshan Hospital undergoing abdominal surgery from Jan 2006 to Dec 2006 were randomly divided into two groups.In the research group, chemically-modified chitosan antiadhesion film was put both at the area of operation and under the incision before closing the abdomen.The recovery procedures were recorded including the recovery of gut movement, the degree and the lasting time of abdominal pain, complication after surgery, the abdominal pain and ileus within 1 year.Result Postoperative incision pain was less significant in research group.The gut function recovered quicker and dietary began earlier.The ratio of early ileus after the surgery decreased significantly.The abdominal adhesion symptom in 1 year after surgery ameliorated significantly.There was no significant difference in other postoperative complications in the two groups.Conclusion The use of chemicallymodified chitosan anti-adhesion film helps to prevent the intestinal adhesion after the abdominal surgery.
