Simultaneous assay of paracetamol and quinine sulphate in antigip F tablet using multi-component analysis (MCA) UV-Vis spectrophotometry
- Author:
Thai Duy Thin
- Publication Type:Journal Article
- Keywords:
antigrip F
- MeSH:
Spectrophotometry;
Acetaminophen;
Quinine
- From:Pharmaceutical Journal
2005;0(11):27-30
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Investigating UV absorption spectrum of paracetamol (5µg/ml, solvent HCl 0.1N) and quinine sulfate (4µg/ml, solvent HCl 0.1N) of antigrip F tablet within the range 200nm to 400nm with HCl 0.1N solution as blank sample showed that: At wavelength 340nm, paracetamol did not absorb, which was not influence to analyze method. The comparison between MCA and normal spectrum method showed that the difference was not statistical significantly α = 0.05 (compared 2 variances, F test, mean values). The advantages of MCA method are rapid, accurate, and solvent-saving. For mixture containing two above ingredients, the content of each formulation’s ingredient can be simultaneous and accurate assayed by measuring absorption level of 4 wavelengths on normal spectrum machine
