The clinical and pathologic features of vascular amyloid deposits of amyloid nephropathy in 6 patients

VernacularTitle:血管壁淀粉样蛋白沉积型淀粉样变性肾病六例临床和病理分析
Author: Guming ZOU ; Bao DONG ; Wenge LI
Publication Type:Journal Article
Keywords: Amyloidosis; Kidney diseases; Pathology,clinical; Amyloid
From: Chinese Journal of Internal Medicine 2011;50(7):576-579
CountryChina
Language:Chinese
Abstract: Objective To analyze clinical and pathologic features of a rare vascular amyloid deposits of amyloid nephropathy ( VADAN) in 6 patients, so as to improve its diagnosis and treatment. Methods All patients received immunopathology, microscopy and electron microscopy examination, and amyloid types were analyzed. Results There were 3 males and 3 females with ages ranging from 52 to 73 years. Two patients suffered from multiple myeloma. Majority patients had slight albuminuria and hematuria. One patient combined with minimal change glomerular disease presented nephrotic syndrome. One patient combined with IgA nephropathy had albuminuria and hematuria. And one patient had myeloma cast nephropathy with acute renal failure. Kidney biopsy proved amyloid deposits along interlobular arterial wall only in all 6 patients. Two cases secondary from multiple myeloma were κ amyloid, and the rests were λ amyloid. Conclusions VADAN is a rare type of amyloid nephropathy. Its clinical manifestation is different from common amyloid nephropathy. Kidney biopsy will benefit its differential diagnosis.