Beneficial effects of intensive therapy on arterial intima-media thickness and its risk factors in type 2 diabetic patients
10.3760/cma.j.issn.1000-6699.2011.06.007
- VernacularTitle:强化治疗对2型糖尿病患者动脉内中膜厚度及其危险因素的影响
- Author:
Na NA
;
Qijin WANG
;
Qin HUANG
;
Changhua DING
;
Zhengkang FENG
;
Hong WU
;
Hui LI
;
Jin LU
;
Maojin XU
;
Dajin ZOU
- Publication Type:Journal Article
- Keywords:
Glycosylation end-products,advanced;
Soluble receptor of advanced glycosylation end-products;
Diabetes mellitus,type 2;
Intima-media thickness of arteries;
Intensive control
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(6):474-477
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the changes of the intima-media thickness(IMT)of carotid and femoral arteries, serum advanced glycosylation end-products(AGEs),and AGEs soluble receptor(sRAGE)after intensively controlling blood glucose, blood pressure, and lipid. Methods One hundred and thirty-two type 2 diabetic patients were divided into 3 groups and followed for 5 years: 20 patients were treated with intensive control of blood glucose and blood pressure, 80 patients with intensive control of blood glucose, blood pressure, and lipid; and 32 patients with conventional therapy. AGEs, sRAGE, and IMT of carotid and femoral arteries were measured and compared among different groups. Results The IMT of carotid and femoral arteries and serum level of AGEs were significantly decreased after intensive treatment. The ratio of sRAGE and HbA1C(sRAGE/HbA1C)were negatively correlated with the mean of HbA1Cin the past five years(r=-0.417, P＜0.001)and the fluctuation of HbA1C(r=-0.309,P＜0.001). Multinomial regression analysis showed that AGEs were the important risk factors of IMT of femoral artery(β=0.152,P=0.068). Conclusion Intensive treatment is significant in controlling the growing IMT of carotid and femoral arteries, while decreasing serum level of AGEs.
