The reference range of serum thyrotropin in iodine-sufficient areas: An epidemiological study
10.3760/cma.j.issn.1000-6699.2011.06.003
- VernacularTitle:碘充足地区血清TSH正常值范围及其影响因素的流行病学研究
- Author:
Chenyan LI
;
Haixia GUAN
;
Xiaochun TENG
;
Yanyan CHEN
;
Yaxin LAI
;
Beibei WANG
;
Fengwei JIANG
;
Jiani WANG
;
Jiashu YU
;
Ningna LI
;
Haibo XUE
;
Mengchun LI
;
He LIU
;
Chenling FAN
;
Hong WANG
;
Hongmei ZHANG
;
Zhongyan SHAN
;
Weiping TENG
- Publication Type:Journal Article
- Keywords:
Thyrotropin;
Reference range;
Thyroid peroxidase antibody;
Thyroglobulin antibody;
Goiter
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(6):458-462
- CountryChina
- Language:Chinese
-
Abstract:
Objective To verify the criteria proposed by National Academy of Clinical Biochemistry(NACB)guidelines in investigating the factors that affect serum TSH determination, and to determine the reference range of serum TSH in iodine-sufficient areas of China. Methods In 2007, 5 348 inhabitants were enrolled from 3 iodine-sufficient areas of Liaoning Province, and were asked to fulfill the questionnaire. Serum TSH, thyroid peroxidase antibody(TPOAb), and thyroglobulin antibody(TgAb)were determined, and thyroid ultrasonography was carried out. Results The distribution of TSH levels was skewed in healthy people and closely fit the curve of Gaussian distribution after logarithmic transformation. The levels of TSH in subjects of 12-19 years of age were significantly higher than those of other age groups(P＜0.01), and no significant difference was found among the latter groups. TSH level in females [(1.68±1.90)mIU/L] was higher than in males[(1.45±1.92)mIU/L, P＜0.01]. The reference range of TSH was 0.43-4.74 mIU/L in males, and 0.48-5.39 mIU/L in females. Family history of thyroid disease, abnormal thyroid ultrasonography, and positive thyroid antibodies were the factors that influenced TSH level. Conclusion The reference range of serum TSH in iodine-sufficient areas of China is established.
