Vaspin,obesity,and type 2 diabetes
10.3760/cma.j.issn.1000-6699.2011.05.028
- VernacularTitle:Vaspin、肥胖及2型糖尿病
- Author:
Shiwei LIU
;
Jinhua WANG
;
Jing YANG
- Publication Type:Journal Article
- Keywords:
Adipokine;
Vaspin;
Obesity;
Diabetes mellitus,type 2;
Insulin resistance
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(5):448-450
- CountryChina
- Language:Chinese
-
Abstract:
Vaspin,a serine protease inhibitor derived from visceral adipose tissue,has been identified as an adipokine with insulin-sensitizing effects in a rat model of type 2 diabetes.Recent studies showed that the administration of recombinant human vaspin significantly improved insulin sensitivity and glucose tolerance,and reversed the expression of genes that may promote insulin resistance in diet-induced obese mice.However,the regulation of serum vaspin concentration in individuals with insulin resistance,and the association of vaspin with obesity,type 2 diabetes,and insulin resistance related disorders remain unclear.
