Effects of tumor suppressor in lung cancer-1 overexpression on gene expressions involved in glucose and lipid metabolism in liver cells
10.3760/cma.j.issn.1000-6699.2011.05.020
- VernacularTitle:肺癌肿瘤抑制因子1基因过表达对肝细胞糖脂代谢相关基因表达的影响
- Author:
Lin DU
;
Gangyi YANG
;
Ling LI
;
Yan YANG
;
Chunmin LU
;
Zongyu MIAO
- Publication Type:Journal Article
- Keywords:
Tumor suppressor in lung cancer-1;
Hepal-6 cells;
Glucose-lipid metabolism;
Gene expression
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(5):429-431
- CountryChina
- Language:Chinese
-
Abstract:
The effects of tumor suppressor in lung cancer-1(TSLC1)upregulation on gene expressions involved in glucose and lipid metabolism in Hepa1-6 cells were investigated.The results showed that TSLC1 overexpression decreased fatty acid synthase and acetyl CoA carboxylase expressions(P<0.05 or P<0.01),increased adipose triglyceride lipase expression(P<0.05),and did not change hormone-sensitive lipase,glucose transporter (GLUT)1,and GLUT4 expressions.These results suggest that TSLC1 overexpression may promote lipolysis and inhibit adipogenesis in liver cells.
