Association of serum ferrltin with β-cell function and insulin resistance in elderly patients with type 2 diabetes and impaired glucose tolerance
10.3760/cma.j.issn.1000-6699.2011.05.010
- VernacularTitle:老年2型糖尿病和糖耐量受损患者血清铁蛋白与胰岛素抵抗和胰岛β细胞功能相关
- Author:
Ying ZHA
;
Jun LIU
;
Jiong XU
;
Heyuan DING
;
Fang WANG
;
Zaoping CHEN
;
Li SHENG
- Publication Type:Journal Article
- Keywords:
Serum ferritin;
Diabetes mellitus,type 2;
Impaired glucose tolerance;
Insulin resistance;
β-cell function
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(5):399-403
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum ferritin and p-cell function,insulin resistance in elderly patients(age>60 years)with type 2 diabetes and impaired glucose tolerance.Methods Total 1143 patients with type 2 diabetes,448 patients with impaired glucose tolerance(IGT),and 2 950 subjects with normal glucose tolerance(NGT)were recruited for the measurments of height,weight,serum triglyceride(TG),total cholesterol,fasting plasma glucose(FPG),fasting insulin(FINS),postprandial 2 h plasma glucose(2hPG),and serum ferritin.Homeostasis model assessment of insulin resistance(HOMA-IR)and QUICK index were used to estimate insulin resistance,and homeostasis model assessment of β cell function(HOMA-p)and disposition index(DI)to evaluate p-cell function.Results The results showed that the level of serum ferritin was significantly higher in type2 diabetes mellitus group than NGT group(P<0.01).HOMA-IR was gradually increased,and HOMA-β,QUICK,and DI decreased from NGT to IGT,type 2 diabetes mellitus groups(all P < 0.05).Spearman and partial correlation analysis showed that partial adjustment for age and sex,serum ferritin was positively associated with FPG,2hPG,TG,FINS,and HOMA-IR,and negatively associated with HOMA-β,QUICK,and DI.Stepwise regression showed that serum ferritin was associated with QUICK,BMI,and TG.Conclusion The results suggest that iron overload exists in elderly patients with type 2 diabetes.With increasing serum ferritin level,insulin resistance increases and p-cell function decreases in the elderly patients with abnormal glucose metabolism.
