Diagnostic value of HbA1C and fasting plasma glucose as early screening parameters for diabetes mellitus
10.3760/cma.j.issn.1000-6699.2011.05.007
- VernacularTitle:糖化血红蛋白和空腹血糖用于早期筛查糖尿病的意义
- Author:
Chunfang YU
;
Jun GE
;
Jingyi LI
;
Jian MENG
;
Wenbin LIU
;
Junjun LIU
- Publication Type:Journal Article
- Keywords:
Fasting plasma glucose;
HbA1C;
Oral glucose tolerance test;
Diabetes mellitus;
Receiver operating characteristic curve
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(5):390-392
- CountryChina
- Language:Chinese
-
Abstract:
The validity of HbA1C and fasting plasma glucose(FPG)for screening of diabetes in community population was investigated.A total of 1 794 subjects from two sub-districts of Yangpu District,Shanghai,underwent a 75 goral glucose tolerance test(OGTT)and HbA1C determination.Based on 1999 World Health Organization criteria,there were 1 411 subjects with normal glucose tolerance(NGT),111 impaired fasting glucose(IFG),73 impaired glucose tolerance(IGT),33 IFG+IGT,and 166 diabetes.According to the receiver operating characteristic curve,the optimal cut-point of FPG for diagnosing diabetes was 6.15 mmol/L with sensitivity of 89.0%,specificity of 92.8%,and area under the curve of 0.959.The cut-point of HbA1C for diagnosing diabetes was 6.5% with a sensitivity and specificity of 71.1% and 80.2%.The area under the curve was 0.822.The screening model using FPG ≥6.1mmol/L and HbA1C≥6.5% had sensitivity of 66.9% and specificity of 97.0%.When the model was FPG ≥6.1 mmol/L or HbA1C ≥6.5%,the sensitivity and specificity was 96.3% and 76.7% respectively.The results suggest that both FPG and HbA1C have good value for screening diabetes in community,and FPG combined with HbA1C may further promote diagnostic efficacy.
