Relationship between HbA1C and microvascular complications in high-risk populations of diabetes
10.3760/cma.j.issn.1000-6699.2011.05.005
- VernacularTitle:糖尿病高风险人群糖化血红蛋白与微血管并发症的关系
- Author:
Xianghang PENG
;
Dehong CAI
;
Rui YANG
;
Xiaohe LU
;
Min FU
;
Yaqin AI
;
Hong CHEN
;
Hua ZHANG
;
Rongping CHEN
- Publication Type:Journal Article
- Keywords:
HbA1C;
Microvascular complications;
Diabetes mellitus;
High-risk populations;
Diagnose
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(5):381-385
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of HbA1C with microvascular complications,and to evaluate the diagnostic value of HbA1C in diabetes mellitus in high-risk populations of Guangzhou.Methods HbA1C,blood glucose,fundus photography,and microalbuminuria were detected in 208 permanent residents with high-risk factors of diabetes.The receiver operating characteristiC(ROC)curves were used to estimate the area of HbA1C,fasting plasma glucose(FPG),postprandial 2 h plasma glucose(2hPG)under the curve for discriminating microvascular complications.Results There were 14.9% adults suffering from diabetic retinopathy and 12% microalbuminuria in high risk populations of diabetes.The optimal cutoff points of HbA1C,FPG,and 2hPG in detecting retinopathy were 5.8%,7.0 mmol/L,and 10.9 mmol/L respectively.The thresholds for increasing prevalence of microalbuminuria were5.8% for HbA1C,6.4 mmol/L for FPG,and 10.7 mmol/L for 2hPG.Conclusions The prevalence of diabetic microvascular complications increases dramatically at the concentration of HbA1C 5.8%.As a diagnostic value for microvascular complications,there is no significant difference between HbA1C and 2hPG.
