Half-effective target effect-site concentration of sufentanil inhibiting urethroscope insertion response when combined with propofol by target-controlled infusion in elderly patients undergoing transurethral resection of prostate
10.3760/cma.j.issn.0254-1416.2011.05.006
- VernacularTitle:舒芬太尼复合TCI异丙酚抑制前列腺电切术老年患者尿道镜置入反应的半数有效效应室靶浓度
- Author:
Jundan JIANG
;
Ting ZHENG
;
Yanqing CHEN
- Publication Type:Journal Article
- Keywords:
Piperidines;
Propofol;
Dose-response relationship;
drug;
Drug delivery systems
- From:
Chinese Journal of Anesthesiology
2011;31(5):542-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the half-effective target effect-site concentration (EC50 ) of sufentanil inhibiting the urethroscope insertion response when combined with propofol by target-controlled infusion (TCI) in the elderly patients undergoing transurethral resection of prostate (TURP) . Methods Twenty-two ASA Ⅰ- Ⅲ patients, aged 65 -79 yr, weighing 47-81 kg, undergoing TURP, were enrolled in the study. Anesthesia was performed with TCI of propofol and sufentanil. The target plasma concentration of propofol was 4 μg/ml. The target effect-site concentration of sufentanil was determined by up-and-down sequential trial. The initial target effect-site concentration of sufentanil was 0.3 ng/ml and the ratio of the target concentrations between the two consecutive patients was 1.1. The ECW and 95% confidence interval of sufentanil required to inhibit the response to urethroscope insertion were calculated. Results The EC50 of sufentanil required to inhibit the urethroscope insertion response was 0.23 ng/ml (95% confidence interval 0.12-0.44 ng/ml). Conclusion When combined with propofol by TCI (target plasma concentration 4 μg/ml), the EC50 of sufentanil inhibiting the response to urethroscope insertion is 0,23 ng/ml in the elderly patients undergoing TURP.
