Distribution of flurbiprofen axetil in cerebral-spinal fluid after intravenous administration
10.3760/cma.j.issn.0254-1416.2011.04.012
- VernacularTitle:氟比洛芬酯静脉注射后在患者脑脊液的分布情况
- Author:
Zhang HONG
;
Feng YI
;
Gu JIAN
- Publication Type:Journal Article
- Keywords:
Flurbiprofen;
Dosage forms;
Cerebrospinal fluid
- From:
Chinese Journal of Anesthesiology
2011;31(4):432-434
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the distribution of flurbiprofen axetil in cerebral-spinal fluid (CSF) by determining the CSF concentration of flurbiprofen after iv administration. Methods Seventy-two ASA Ⅰ or Ⅱ patients of both sexes aged 18-75 yr weighing 54-82 kg undergoing spinal or combined spinal-epidural anesthesia for lower extremity or lower abdominal surgery were studied. Flurbiprofen axetil 1 mg/kg was injected intravenously.CSF 2 ml and venous blood 3 ml were obtained simultaneously every 5 min after iv injection for 45 min (T1-9 ) for determination of flurbiprofen concentration using high performance liquid chromatography, and the CSF/blood flurbiprofen concentration ratio was caculated. Results Flurbiprofen was not detected in CSF at T1,2 after iv injection in 3 and 4 patients. The CSF flurbiprofen concentration was significantly higher at T4-9, and CSF/blood flubiprofen concentration ratio higher at T5-9 than at T3 ( P ＜ 0.05). There was no significant difference in CSF flurbiprofen concentrations among T4-9 ( P ＞ 0.05 ) Conclusion Flurbiprofen is detected in CSF after iv injection, the CSF flurbiprofen concentration peaks at 20 min after iv injection and it lasts until 45 min after iv injection.
