Effects of different target effect-site concentrations of remifentanil on the sedative effect of propofol
10.3760/cma.j.issn.0254-1416.2011.04.008
- VernacularTitle:不同效应室靶浓度瑞芬太尼对患者异丙酚镇静效应的影响
- Author:
Lingling DING
;
Weixiu YUAN
;
Weidong MI
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
Piperidines;
Propofol;
Conscious sedation;
Drug delivery system
- From:
Chinese Journal of Anesthesiology
2011;31(4):419-421
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of different target effect-site concentrations (Ces) of remifentanil on the sedative effect of propofol. Methods Fifty ASA Ⅰ or Ⅱ patients aged 20-55 yr weighing 48-86 kg with body mass index ＜ 30 kg/m2 were randomly divided into 5 groups ( n = 10 each) . Anesthesia was induced with TCI of remifentanil (Ce = 0, 2, 4, 6 and 8 ng/ml in groups R0-R4 respectively) and propofol. The initial Ce of propofol was 2.0 μg/ml in the 5 groups, and then the Ce of propofol increased by 0.5 μg/ml every 1 min until BIS value decreased to 50. BIS value and Ce of propofol were recorded as the patient lost consciousness. The effect-site concentration and consumption of propofol and the time required were recorded when BIS value decreased to 50.Results BIS value was significantly increased, while the effect-site concentration of propofol was significantly decreased as the patient lost consciousness, and the effect-site concentration and consumption of propofol were significantly decreased and the time required was shortened when BIS value decreased to 50 in R2-R4 groups compared with group R0 (P ＜ 0.05 or 0.01) . Conclusion The sedative effect of propofol can be enhanced when the Ce of remifentanil reaches 4 ng/ml, and the effects are comparable when the Ce of remifentanil reaches 4, 6 and 8 ng/ml.
