Study of the influence of Yifei-Kangxin capsule on MMP-1 of rats model with pulmonary heart disease

VernacularTitle:益肺康心胶囊对大鼠慢性肺源性心脏病模型MMP-1的影响
Author: Qun LIANG ; Xicheng JIANG ; Haikun WU
Publication Type:Journal Article
Keywords: Yifei-Kangxin capsule; Pulmonary heart disease; Matrix metalloproteinase-1
From: International Journal of Traditional Chinese Medicine 2011;33(6):508-510
CountryChina
Language:Chinese
Abstract: Objective To discuss the influence of Yifei-Kangxin capsule on MMP-1 in Wistar rats model with pulmonary heart disease. Methods 40 Wistar rats with pulmonary heart disease were averagely grouped as Normal Group, Model Group, Therapeutic Group and Comparative Group randomly by weight. The rats in Therapeutic Group were given Yifei-Kangxin capsule and the rats in Comparative Group were given Nifedipine. The course of treatment was 15 days. The rats were killed at the next 7th, 14th and 28th day separately to test MMP-1 in pulmonary tissue. Results After the treatment, the expression of MMP-1 in pulmonary tissue of the Therapeutic Group[7 d, 14 d, 28 d was(0.231±0.017)ng/m、(0.308±0.081)ng/m、(0.358±0.074)ng/m]was lower than the Model Group[7 d, 14 d, 28 d was(0.266±0.036)ng/m 、(0.315± 0.060)ng/m、(0.612±0.091)ng/m]. Conclusion Yifei-Kangxin capsule can inhibit the expression of MMP-1 in the rats model pulmonary heart disease.