Effect of nateglinide or sequential treatment with metformin on glycemic stability in newly diagnosed type 2 diabetic patients

VernacularTitle:那格列奈单药或序贯二甲双胍治疗对初诊2型糖尿病患者血糖稳定性的影响
Author: Xueqin WANG ; Jianbin SU ; Jinfeng CHEN ; Yan JIN ; Feng XU
Publication Type:Journal Article
Keywords: Nateglinide; Diabetes mellitus,type 2
From: Chinese Journal of Endocrinology and Metabolism 2011;27(7):584-585
CountryChina
Language:Chinese
Abstract: The effect of nateglinide or sequential treatment with metformin on glycemic stability in newly diagnosed type 2 diabetes was investigated. Thirty-four cases of newly diagnosed type 2 diabetes received nateglinide therapy, or sequential treatment with metformin according to fasting and postprandial blood glucose, and were classified into isolated nateglinide therapy group(n=14) and sequentially treated with metformin group(n=20). Glycemic stability, reflected by mean amplitude of glycemic excursions(MAGE) and HbA1C, was determined in all patients before and after therapy for three months. HbA1C and MAGE in two groups were all improved after treatment(P＜0.05). The therapy of nateglinide alone or combined with metformin can significantly improve glycemic stability in newly diagnosed type 2 diabetes.