The function of hepatic oval cells under high glucose condition in vivo
10.3760/cma.j.issn.1000-6699.2011.07.017
- VernacularTitle:体内高糖环境下肝脏卵圆细胞的功能研究
- Author:
Ying LI
;
Lijuan ZHAO
;
Yanxiang LI
;
Fangzhen XIA
;
Yingli LU
- Publication Type:Journal Article
- Keywords:
High glucose;
Hepatic oval cell;
Insulin-producing cell;
in vivo
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(7):604-606
- CountryChina
- Language:Chinese
-
Abstract:
Rat hepatic oval cell model was induced by hyperglycemia and streptozotocin in vivo. Expression of insulin and mRNA expression of pancreatic transcription factors(Nkx6.1, PDX-1) were carried out. It showed that under high glucose, liver tissues were positive for insulin staining, the expression of Nkx6.1 and Pdx-1mRNA was significantly enhanced, and insulin-1mRNA was found to be expressed. The result suggests that under high glucose, hepatic oval cells can differentiate into insulin-producing cells.
