Changes of serum gastrin and CCK2R expression of visceral adipocytes in catch-up rats

VernacularTitle:追赶生长大鼠胃泌素及内脏脂肪细胞CCK2R表达变化
Author: Huiqing LI ; Lulu CHEN ; Xiuling DENG ; Jiaoyue ZHANG ; Yunfei LIAO ; Zhenhua LIU ; Huijie SONG
Publication Type:Journal Article
Keywords: Catch-up growth; Gastrin; Adipocyte; CCK2R
From: Chinese Journal of Endocrinology and Metabolism 2011;27(7):607-609
CountryChina
Language:Chinese
Abstract: Wistar rats(n=24) were divided into normal control group(NC), food restriction group(FR), and catch-up group(RN). Serum glucose,lipids, gastrin, the ratio of visceral fat to body fat, adipocyte CCK2R mRNA and protein levels were determined. Compared with NC group, FR rats had lower serum gastrin and visceral fat formation. The adipocyte CCK2R mRNA and protein levels of FR rats were lower than those of NC rats. Serum gastrin level of RN rats was higher than those of FR and NC rats(P＜0.05). The ratio of visceral fat to body fat in RN rats increased compared with FR rats and was close to that of NC rats. The adipocyte CCK2R mRNA and protein levels of RN rats were higher than those of FR and NC rats. Gastrin and its receptor pathway possibly play a role in the mechanism of visceral fat accumulation in catch-up rats.