Hypoxia-inducible factor-l attributing to tumor angiogenesis
10.3760/cma.j.issn.1673-422X.2011.05.003
- VernacularTitle:低氧诱导因子-1促进肿瘤血管生成的研究
- Author:
Xiaohui WANG
;
Weidong ZHANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Hypoxia-inducible factor-l;
Vascular endothelial growth factors;
Angiopoietins
- From:
Journal of International Oncology
2011;38(5):329-332
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor-1 ( HIF-1 ) is one of the most important transcriptional factors which regulate the transcription of vascular endothelial growth factor ( VEGF ), HIF-1 plays a critical role in tumor angiogenesis and metastasis. The transcriptional regulation role for HIF-1 in tumor angiogenesis is closely related to its molecular structure,biological character and molecular mechanism and signaling pathways.
