NKG2D and its ligands in tumor immunotherapy
10.3760/cma.j.issn.1673-422X.2011.05.009
- VernacularTitle:NKG2D及其配体与肿瘤免疫治疗研究新进展
- Author:
Chengying ZHU
;
Junping ZHANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Immunotherapy;
Biological therapy
- From:
Journal of International Oncology
2011;38(5):349-351
- CountryChina
- Language:Chinese
-
Abstract:
Natural killer group 2,member D (NKG2D) is a C-typelectin-like activating receptors on natural killer cells surface. NKG2D engaging with the ligands on tumor cells surface can eliminate tumor cells. However,there must exist immune escape mechanisms in tumor mice and cancer patients. Recently, molecular biological techniques are used to regulate the expression of the receptors and ligands to break the immune evasion.
