Clinical effect of intra-articular injection of sodium hyaluronate combined with rehabilitation training in treatment of knee osteoarthritis in the elderly
10.3760/cma.j.issn.0254-9026.2011.05.009
- VernacularTitle:关节腔内注射联合康复训练治疗膝关节骨性关节炎临床观察
- Author:
Zhiming ZHANG
- Publication Type:Journal Article
- Keywords:
Osteoarthritis,knee;
Hyaluronic acid;
Rehabilitation;
βeta-endorphin;
Substance P
- From:
Chinese Journal of Geriatrics
2011;30(5):384-386
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of intra-articular injection of sodium hyaluronate combined with rehabilitation training in treatment of knee osteoarthritis, and their effects on β endorphin and substance P levels in plasma. Methods All 106 cases with knee osteoarthritis were divided into treatment group and control group. Treatment group were treated by intra-articular injection of sodium hyaluronate combined with rehabilitation training, and control group underwent rehabilitation training only. Knee joint function was evaluated using Lysholm scores before and six weeks after treatment, and at 3-month and 6-month follow-up. Meanwhile, the concentrations of β endorphin and substance P in plasma were tested in the two groups. Results Compared with pre- treatment, the Lysholm scores were obviously increased after 6-week treatment, at 3-month and 6-month follow-up in both groups, with more obvious increase in treatment versus control group (P＜0.01). The Lysholm scores were higher in treatment group than in control group (P＜0.01). The concentration of β endorphin in plasma was significantly increased, and the substance P concentration in plasma was decreased after treatment in both groups. There were also significant differences in concentrations of β endorphin and substance P in plasma between treatment group and control group (P＜0.01). Conclusions Intra-articular injection of sodium hyaluronate combined with rehabilitation training is effective in improving knee joint function in elderly patients, in relieving pain and in enhancing joint movement.
