Risk factors and drug-resistance of Pseudomonas aeruginosa infection in intensive care unit
10.3760/cma.j.issn.1674-2397.2011.03.003
- VernacularTitle:重症监护病房铜绿假单胞菌感染的危险因素和耐药性分析
- Author:
Xinbiao HE
;
Wei ZHAO
- Publication Type:Journal Article
- Keywords:
Pseudomonas aeruginosa;
Drug resistance;
Risk factor
- From:
Chinese Journal of Clinical Infectious Diseases
2011;4(3):135-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the incidence, risk factors and drug-resistance of Pseudomonas aeruginosa infection in intensive care unit (ICU). Methods Totally 171 patients with sepsis admitted in ICU were enrolled. Pathogenic bacteria culture and antimicrobial susceptibility tests were performed. SPSS10. 0 software was used for Logistic regression analysis of the risk factors. Results Pseudomonas aeruginosa infection was confirmed in 37 patients, and 45 strains of Pseudomonas aeruginosa were isolated. Logistic regression revealed that recent antibiotics use ( OR = 4. 291 , 95% CI: 1. 727-10. 662) , length of ICU stay (OR = 1.117, 95% CI: 1.058-1. 181) , mechanical ventilation (OR = 3.400, 95% CI: 1.348-8.579) and central venous catheterization (OR =3. 339, 95% CI: 1.322-8.434) were independent risk factors of Pseudomonas aeruginosa infection. The resistance rate of cefotaxime was the highest (68.9%) and 18 strains (40%) were multidrug-resistant. Conclusions Pseudomonas aeruginosa infection is common in ICU and it is usually multidrug resistant. The rational use of antibiotics and aseptic technique of invasive catheterization are important for the prevention of Pseudomonas aeruginosa infection.
