Molecular mechanism of benign biliary stricture and biological therapy
10.3760/cma.j.issn.1007-8118.2011.06.023
- VernacularTitle:良性胆管狭窄发生的分子学机制及生物治疗
- Author:
Xiangyu WANG
;
Lijun LI
;
Zhiqiang ZHENG
- Publication Type:Journal Article
- Keywords:
Benign biliary strictures;
Molecular mechanism;
Biological therapy
- From:
Chinese Journal of Hepatobiliary Surgery
2011;17(6):518-520
- CountryChina
- Language:Chinese
-
Abstract:
Benign biliary strictures(BBS) have different etiologies, and the most common causes are strictures secondary to iatrogenic and ischemic injury after hepatobiliary and transplantation surgery. Fibroblast proliferating activity, extracellular matrix overdeposition and scar proliferation are closely related to BBS. The mechanism of development of BBS involves a variety of cells, cytokines and extracellular matrix. In recent years, biological treatment is emerging as an effective option for BBS, but the clinical application is not yet mature and the curative effect needs to be evaluated further in the future.
