Research progress of neural invasion of pancreatic cancer
10.3760/cma.j.issn.1007-8118.2011.06.022
- VernacularTitle:胰腺癌神经浸润及临床研究新进展
- Author:
Baoxun WANG
;
Qunhua ZHANG
- Publication Type:Journal Article
- Keywords:
Pancreatic cancer;
Perineural invasion;
Pain;
Hyperglycemia;
Optogenentics
- From:
Chinese Journal of Hepatobiliary Surgery
2011;17(6):515-517
- CountryChina
- Language:Chinese
-
Abstract:
The high occurrence of neural invasion in pancreatic carcinoma, which can be as much as 90%-l00%,leads to the poor survival rate in patients. The classical pathology includes invasion of both the extrapancreatic and intrapancreatic neurons. Metastasis into the extrapancreatic plexus promotes invasion into the intrapancreatic neurons and therefore results in pain. An increased in the diagnosis of new-onset diabetes mellitus, on the other hand, correlates with an increase in pancreatic cancer. This implies that hyperglycemia may promote neural invasion of pancreatic carcinoma. Novel auxiliary therapy of pancreatic carcinoma with neural invasion includes controlling of blood sugar and optogenetics, a new genetic technology which can further be utilized for surveillance.
