Prophylactic antibiotics in severe acute pancreatitis: a meta-analysis

VernacularTitle:重症急性胰腺炎预防性应用抗生素的Meta分析
Author: Di ZHANG ; Feng CAO ; Fei LI ; Jiabang SUN
Publication Type:Journal Article
Keywords: Severe acute pancreatitis; Prophylactic antibiotics; Meta-analysis
From: Chinese Journal of Hepatobiliary Surgery 2011;17(6):466-470
CountryChina
Language:Chinese
Abstract: Objective To carry out a meta-analysis on the published data in order to evaluate the clinical efficacy of prophylactic antibiotics in severe acute pancreatitis (SAP). Methods We searched the MEDLINE, EMBASE, Cochrane data base for systematic reviews and China biological medicine for randomized controlled trials on the efficacy of prophylactic antibiotics in patients with SAP from 1975 to May 2010. Eight studies met the inclusion criteria. Two authors independently extracted the data from these studies. The data were analyzed using the RevMan 4. 2. 10 software. Result In patients with SAP, prophylactic antibiotics did not reduce pancreatic infection (OR = 0. 67,95% CI:0. 43～1. 02,P = 0. 06), surgical intervention (OR = 0. 90,95% CI: 0. 60～ 1. 36 ,P = 0. 63) and mortality rate (OR = 0. 69,95% CI: 0. 41～1. 15,P=0. 16). Conclusion Antibiotic prophylaxis of SAP did not reduce mortality. It did not protect against pancreatic infection and the frequency of surgical intervention.