Importance of early intestinal barrier protection in severe acute pancreatitis
10.3760/cma.j.issn.1007-8118.2011.06.008
- VernacularTitle:早期肠屏障功能保护在重症急性胰腺炎治疗中的重要性
- Author:
Yongpeng DIAO
;
Hong CHEN
;
Fei LI
;
Lei YANG
;
Dachuan LIU
;
Yan ZHU
;
Qing XU
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Intestinal barrier;
Prognosis
- From:
Chinese Journal of Hepatobiliary Surgery
2011;17(6):462-465
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of early intestinal barrier protection in patients with severe acute pancreatitis(SAP). Methods To analyze the therapeutic methods and prognosis of 56 patients with SAP. The patients were randomly divided into the conventional therapy group (A) and the intestinal barrier protection group (B). The APACHE Ⅱ score, Ranson score, Marshall score, CT severity index (CTSI), gastrointestinal functions score (GFS), the ratio of Lactulose to Mannitol (L/M), plasma Endotoxin and Diamine Oxidase (DAO), serum C-reactive protein (CRP) and TNF-α, incidence of pancreatic infection and multiorgan dysfunction syndrome (MODS), and the hospitalization mortality were compared between the two groups. Results On the 7th day after admission, the APACHE Ⅱ score, GFS, L/M, Endotoxin, DAO, CRP and TNF-α were significantly less in group B than in group A (P<0. 05). There was no significant difference in the CTSI (P>0. 05)between the two groups at 2nd week after admission. The incidence of pancreatic infection and MODS in group B were significantly lower than in group A (P<0. 05). The hospitalization mortality was not significantly different (P>0. 05) between the two groups. Conclusion Early intestinal barrier protection in SAP alleviated systemic inflammatory response, and reduced the incidences of pancreatic infection and MODS, thus improved the prognosis.
