Analysis of expression of von Willebrand factor, endothelin-1, vascular endothelial growth factor in Budd-Chiari syndrome with membranous obstruction
10.3760/cma.j.issn.1005-1201.2011.06.018
- VernacularTitle:血管性血友病因子、内皮素-1和血管内皮生长因子在下腔静脉隔膜型布-加综合征中异常表达的意义
- Author:
Xinqiang HAN
;
Maoheng ZU
- Publication Type:Journal Article
- Keywords:
Hepatic vein thrombosis;
Factor Ⅷ;
Endothelin A;
Vascular endothelial growth factors
- From:
Chinese Journal of Radiology
2011;45(6):580-583
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether the injured vascular endothelial plays an important role in the membranous formation of the inferior vena cava (IVC). Methods There were 40 cases of membranous obstruction of inferior vena cava (MOVC) in the experimental group and 40 arrhythmic inpatients in the control group from affiliated hospital .There were 23 males and 17 females in experimental group while 21 males and 19 females in control group, and the age were (41.8±8.1) yrs and (43.2±7.6) yrs respectively. All of them had no anti-coagulation (clotting) drug history and smoking history, no hypertension, no pulmonary artery hypertension, no coronary heart disease, no valvular disease, no myocardial disease, no blood disease, no diabetes, no connective tissue disease and malignancy, and liver and renal function must be normal. And then the serum concentrations of von Willebrand factor(vWF), endothelin-1(ET-1), vascular endothelial growth factor(VEGF) were defined by enzyme-linked immunosorbent assay (ELISA). The results were analyzed with independent sample t-test. Results In MOVC patients, the serum concentrations of vWF, ET-1 and VEGF[ (37.8±6.6) μg/L, (31.9±6.0) ng/L, (20.84±5.78) μg/L] were higher than those in the control group[ (3.3±1.3) μg/L, (5.3±1.8) ng/L, (4.2±1.2) μg/L. t=32.65,26.70,17.85,P＜0.01, respectively]. ConclusionsThe injury of vascular endothelium is related to the formation of membrane in the IVC.
