Investigating the correlation between PTPN22 C1858T polymorphism and rheumatoid arthritis in Han nationality in Xiamen area

VernacularTitle:厦门地区汉族人PTPN22C1858T基因多态性与类风湿关节炎的关系研究
Author: Zhenxing XU ; Jinchun CHEN ; Mingshan QIU ; Jing TENG ; Ming XU
Publication Type:Journal Article
Keywords: Arthritis,rheumatoid; Polymorphism,single nucleotide; Protein-tyrosine-phosphatase; Polymerase chain reaction
From: Chinese Journal of Rheumatology 2011;15(7):472-475
CountryChina
Language:Chinese
Abstract: Objective To assess the correlation between FFPN22 C1858T polymorphism and rheumatoid arthritis(RA)in Han people in Xiamen area by TaqMan-MGB real-time PCR．Methods A casecontrol study was carried out in Xiamen Han population．Their blood samples(100 RAs and 100 controls respectively)were collected and the PTPN22 C1858T polymnrphism was tested by TaqMan-MGB real-time PCR．Results①A technique of TaqMan-MGB teal-time PCR was established to investigate PTPN22 C1858T polymorphism；② Onlv 1858 C allele was presented in all the RAs and controls，and no T allele was detected．Conclusion There is no PTPN22 1858T allele in Han people in Xiamen area．It is suggested that there's no association between PTPN22 C1858T polymorphism and RA．