Low molecule weight IgM in ankylosing spondylitis and rheumatoid arthritis

VernacularTitle:强直性脊柱炎和类风湿关节炎患者低相对分子质量IgM水平的研究
Author: Luding ZHANG ; Libin ZHANG ; Huiqi LU ; Xin WU ; Ling ZHOU ; Xiaoping YANG ; Huji XU
Publication Type:Journal Article
Keywords: Immunoglobulin M; Spondylitis,ankylosing; Arthritis,rheumatoid
From: Chinese Journal of Rheumatology 2011;15(6):404-406
CountryChina
Language:Chinese
Abstract: Objective To study the serum levels of low molecule weight IgM (LMW IgM) in ankylosing spondylitis (AS) patients and rheumatoid arthritis (RA) patients and to evaluate the relationship of LMW IgM levels with the disease activities. Methods The levels of LMW IgM and pentameric IgM in AS patients, RA patients and healthy controls were measured with ELISA after separated using ultrafiltration assay. Differences in the percentage of LMW IgM between subject groups were analysed using Mann-Whitney U test. Results The percentages of LMW IgM increased dramatically in AS patients and RA patients compared with healthy controls (0.194 ± 0123, 0.061 ±0.026, 0.028 ±0.165 separately). The LMW IgM percentages were not correlated with the disease activities. Conclusion The increase of LMW IgM indicates humoral immune function abnormality in AS patients and RA. However, the mechanism needs further study.